HCN Channels—Modulators of Cardiac and Neuronal Excitability

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HCN Channels—Modulators of Cardiac and Neuronal Excitability

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels comprise a family of cation channels activated by hyperpolarized membrane potentials and stimulated by intracellular cyclic nucleotides. The four members of this family, HCN1-4, show distinct biophysical properties which are most evident in the kinetics of activation and deactivation, the sensitivity towards cyclic nucleotides a...

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P3: Neuronal Death Following Posttraumatic Excitability and Seizure

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Neuronal injury and death following focal mild brain injury: The role of network excitability and seizure

Objective(s): While traumatic brain injury (TBI) is a predisposing factor for development of post-traumatic epilepsy (PTE), the occurrence of seizures following brain trauma can infuriate adverse consequences of brain injury. However, the effect of seizures in epileptogenesis after mild TBI cannot yet be accurately confirmed. This study was designed to investigate the ...

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Protein kinases and neuronal excitability

Like most cells, neurons are regulated by intracellular second messengers formed in response to extracellular signals. Among the components of a neuron that are subject to regulation are its complement of ion channels, which determine the neuron's intrinsic electrical properties. Modulation of these electrical properties influences both the responsiveness of neurons and their capacity to signal...

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p3: neuronal death following posttraumatic excitability and seizure

seizure may occur after mild traumatic brain injury (tbi), and the severity of tbi can be considered the most crucial factor for an increased risk of recurring seizures as well as for the development of posttraumatic epilepsy. however, the effect of seizures in epileptogenesis after mild tbi cannot yet be accurately confirmed. this study was designed to determine whether mild tbi increases seiz...

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ژورنال

عنوان ژورنال: International Journal of Molecular Sciences

سال: 2015

ISSN: 1422-0067

DOI: 10.3390/ijms16011429